President Donald Trump has issued an Executive Order to initiate the Genesis Mission, a new national effort led by the U.S. Department of Energy (DOE) aimed at transforming American science and innovation through artificial intelligence (AI). The initiative seeks to strengthen the United States’ technological leadership and global competitiveness.
The Genesis Mission is designed to leverage advances in AI and computing to double the productivity and impact of American science and engineering within ten years. Its goals include securing American energy dominance, accelerating scientific discovery, and enhancing national security.
“Throughout history, from the Manhattan Project to the Apollo mission, our nation’s brightest minds and industries have answered the call when their nation needed them,” said Secretary of Energy Chris Wright. “Today, the United States is calling on them once again. Under President Trump’s leadership, the Genesis Mission will unleash the full power of our National Laboratories, supercomputers, and data resources to ensure that America is the global leader in artificial intelligence and to usher in a new golden era of American discovery.”
This announcement follows President Trump’s earlier Executive Order focused on removing barriers to American leadership in AI as well as his America’s AI Action Plan released this year. These directives aim to foster innovation, reduce reliance on foreign adversaries for technology, and fully utilize America’s scientific capabilities.
Secretary Wright has appointed Dr. Darío Gil, Under Secretary for Science, as director of the Genesis Mission. The initiative will involve all 17 DOE National Laboratories along with industry partners and academic institutions in creating an integrated discovery platform. This platform will connect leading supercomputers, AI systems, quantum technologies, and advanced scientific instruments across the country.
Once operational, this system is expected to be one of the most complex scientific instruments ever built. It will draw on expertise from approximately 40,000 DOE scientists and technical staff alongside private sector innovators.
The Genesis Mission will focus on three main areas: accelerating advancements in nuclear energy production—including fusion—and modernizing energy grids using AI; supporting quantum ecosystem development for future discoveries; and deploying advanced AI technologies for national security purposes such as maintaining nuclear stockpile safety.
Under Secretary for Science Dr. Darío Gil stated: “The Genesis Mission marks a defining moment for the next era of American science. We are linking the nation’s most advanced facilities, data, and computing into one closed-loop system to create a scientific instrument for the ages, an engine for discovery that doubles R&D productivity and solves challenges once thought impossible.”
Brandon Williams, Administrator of the National Nuclear Security Administration (NNSA), added: “The Genesis Mission represents the next great chapter and an unparalleled opportunity for America’s scientific and national security leadership.
Building on decades of innovation and collaboration across our national laboratories, NNSA will leverage AI, quantum computing, and advanced data analytics that will strengthen our deterrents and ensure the United States maintains an unmatched strategic edge over our adversaries. Under President Trump’s leadership, this mission will embody the very best of American ingenuity, turning science and innovation into security.”
Dr. John Wagner—Chair of DOE’s National Laboratory Directors’ Council—commented: “DOE’s National Laboratories are engines of discovery that keep the United States competitive and secure. The Genesis Mission unlocks the full potential of these institutions by giving our scientists and engineers tools to work at the speed of innovation. Our laboratories have always risen to meet the nation’s greatest challenges, and this initiative ensures we continue that legacy in the age of artificial intelligence.”
